Our principal Investigator Prof Wolfram Ruf of the University Medical Center Mainz has been elected as the next president of the International Society on Thrombosis and Hemostasis (ISTH).
The ISTH is the leading worldwide organization dedicated to the advancement of the understanding, prevention, diagnosis and treatment of thrombotic and bleeding disorders.
Dissemination of inflammatory cells and molecules from the intestine to downstream and distal organs
08.05.2024, 17 - 17:45 Uhr
Emil R. Unanue Professor of Immunobiology, Department of Pathology
Washington University in St. Louis, USA
Modern lipidomics approaches for clinical and preclinical research and profiling
18.04.2024, 17 - 17:45 Uhr
Clinical Lipidomics Unit, Institute of Physiological Chemistry
University Medical Center Mainz
curAFellows are aimed at students who would like to gain first practical experience in interdisciplinary research projects in the field of translational research. A unique opportunity to make a valuable contribution to the fight against atherothrombosis at an early stage.
Der 1. curATime Hackathon wird am 08.+09.04.2024 im Gutenberg Digital Hub, Mainz, stattfinden.
Gemeinsam werden junge Wissenschaftler, Bioinformatiker und Healthcare-Begeisterte Herausforderungen aus der Forschung des curATime Clusters angehen. Mehr Informationen hier.
The curATalk lecture series was created in 2021 in order to connect the scientists that are involved in curATime as well as thematically closely related scientist and their research. This virtual meeting takes place at regular intervals and presents their latest research findings and topics that provide additional scientific value for the individual curATime projects. The curATalks are announced publicly and enjoy lively participation from a broad audience.
Dissemination of inflammatory cells and molecules from the intestine to downstream and distal organs
08.05.2024, 17 - 17:45 Uhr
Emil R. Unanue Professor of Immunobiology, Department of Pathology
Washington University in St. Louis, USA
Modern lipidomics approaches for clinical and preclinical research and profiling
18.04.2024, 17 - 17:45 Uhr
Clinical Lipidomics Unit, Institute of Physiological Chemistry
University Medical Center Mainz
Macrophage-targeted RNA therapeutics
15.01.2024, 17 - 17:45 Uhr
Prof. Dr. Dr. Stefan Engelhardt
Institute of Pharmacology and Toxicology
Technical University of Munich
Speaker of the CNATM Cluster
Microbiota and Arterial Thrombosis
08.11.2023, 17 - 17:45 Uhr
Jun.-Prof. Dr. Christoph Reinhardt
Center for Thrombosis and Haemostasis
University Medical Center Mainz, Germany
Protein Protein interaction prediction in our AI based Genomics and Proteomics Sequence Analysis Framework
08.08.2023, 17 - 17:45 Uhr
Dr. Muhammad Nabeel Asim
DFKI GmbH
Kaiserslautern, Germany
Breaking Tolerance: The Autoimmune Aspect of Atherosclerosis
12.06.2023, 17 - 17:45 Uhr
Prof. Dr. Klaus Ley
Immunology Center of Georgia
Augusta University, USA
Synthetic regeneration at the heart of reversible reprogramming
25.05.2023, 17:00 - 17:45 Uhr
Dr. Johnny Kim
TRON gGmbH, Mainz
„Humoral“ Immunity and Immune Homeostasis in Atherosclerosis
23.11.2022, 17:00 - 17:45 Uhr
Prof. Dr. Christoph Binder
Department of Laboratory Medicine Medical University of Vienna & Center for Molecular Medicine of the Austrian Academy of Sciences
Blockchain as Digital Access Gate to Medical Data
21.03.2023, 17:00 - 17:45 Uhr
Dr. Markus Jostock
Arxum GmbH, Kaiserslautern
Acute coronary syndrome – novel pathophysiologic insights call for precision prevention
17.01.2023, 17:00 - 17:45 Uhr
Prof. Dr. David M. Leistner
Med. Clinic 3 – Cardiology, Angiology, University Hospital Frankfurt
Macromolecular strategies for enhancing immunotherapy responses to treat cardiovascular diseases
06.09.2022, 17:00 - 17:45 Uhr
Julius Maximilian University Würzburg
Inflammation of the heart: Mechanism and therapeutic options
21.07.2022, 16:00 – 16:45 Uhr
Prof. Dr. med. Florian Leuschner
Heidelberg University Hospital
Atherothrombosis: the impact of clotting proteases
21.06.2022 17:30 - 18:15 Uhr
Prof. Hugo ten Cate
CARIM, Maastricht University Medical Center+
RNA therapeutics in cardiovascular disease
12.04.2022, 17:00 - 18:00 Uhr
Prof. Dr. Stefanie Dimmeler
Goethe- University, Frankfurt
Institute of Cardiovascular Regeneration, Centre for Molecular Medicine
Chemometrics strategies and tools in Precision Medicine
23.03.2022 17:30 - 18:15 Uhr
Prof. Johan Trygg
Departmentof Chemistry, Umeå University, Umeå, Sweden
Corporate Research, Sartorius, Umeå, Sweden
Artificial CRISPR, an AI based approach to predict signature drug response from multi-omics datasets
22.03.2022, 17:30 - 18:15 Uhr
Prof. Dr. Jürgen Scheele
Chief Medical Officer Innoplexus AG
Advancing Robust Signal Processing and Statistical Learning for Biomedical Applications
15.02.2022, 17:30 - 18:15 Uhr
Prof. Dr.-Ing. Abdelhak Zoubir
Signal Processing Group, Technical University of Darmstadt
Human gut microbiota variation in health and disease
02.02.2022, 17:00 – 17:45 Uhr
Laboratory of Molecular Bacteriology (Rega Institute), KU Leuven, Belgium
Symptoma – Every patient deserves the right diagnosisand treatment
24.01.2022, 17:00 - 17:45 Uhr
Dr. med-univ. Jama Nateqi
Mass spectrometry-based proteomics in translational research and systems medicine
15.12.2021, 17:30 – 18:15 Uhr
Univ.-Prof. Dr. rer. nat. Stefan Tenzer
Institut für Immunologie, Universitätsmedizin Mainz
Innovate the future of Life Science and Medicine
curAHack has brought together young scientists, bioinformaticians and healthcare-enthusiasts to tackle research challenges from the curATime cluster. With guidance from mentors and experts, participants have developed innovative solutions presented their ideas to a jury at the end of the event. More information about the challenges and the event itself can be found here.
The mentors of the three challenges draw an enthusiastic conclusion:
"Team 1 , "curAGUI" was required to create a GUI that was able to implement all of the placeholder scripts provided in order to further on be able to replace them with trained deep learning models. The team was able to develop a basic framework that meant to envelop all of the required points and integrated videos in a manner that would mimic the results of the pipeline."
Aida Romano Martínez, University Medical Center Mainz
"During the hackathon, two teams worked on an RNA-seq analysis pipeline that should not require any gene annotation information for initial analysis. Both teams were able to conduct exploratory analysis to quantify the effect of different ensemble gene annotation models. As a solution, both teams came up with k-mer count tables as an intermediate result file that can later be mapped to any gene annotation.
While one team, the "Bioinformagicians", established an analysis pipeline using existing tools that they cleverly selected and adapted for the intended use, the other team, the "Expressionists", developed a novel analysis from scratch. The Bioinformagicians ultimately won the hackathon with a combined analysis that could be the basis for the development of novel expression pipeline for RNA-seq data. We will summarize all results and findings in a preprint and make all data, code, and analysis available as public repository and on a preprint server."
Dr. David Weber, TRON gGmbH
"The Hackathon challenge “Target Sequence for RNA delivery” was tackled by the team “CurApollo13” that aimed to identify peptide sequences that could enable targeted delivery of nanoparticles to endothelial cells within atherosclerotic lesions. Without any prior knowledge or computational resources, the team came up with two creative and yet complementary concepts. One approach involved analysis of 3D protein structures of paratope/epitope pairs.
In a second approach, the CurApollo13-team provided a concept wherein 3D structures of random short peptide sequences could be computationally predicted using AlphaFold, a powerful computational method that can simulate 3D protein structures. Conceptually, these putative structures could be superimposed on to antigens to test their putative binding. In principle, the first approach could be used to validate the second, fully computational approach. Team CurApollo13 finished as the runners-up of the curAHack."
Dr. Johnny Kim, TRON gGmbH
curAHack 2024 at the Gutenberg Digital Hub at the Zollhafen Mainz.
