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  • curATalk Alice Assinger - 13.06.2024

    Platelets in Infection: A Battle of Wits

    13.06.2024, 17:15 - 18:15

    Prof. Dr. Alice Assinger

    Institute of Vascular Biology and Thrombosis Research,

    Medical University of Vienna, Austria

    The seminar will be held on-site at University Medical Center Mainz, Building 708

  • Prof Wolfram Ruf next ISTH president

    Our principal Investigator Prof Wolfram Ruf of the University Medical Center Mainz has been elected as the next president of the International Society on Thrombosis and Hemostasis (ISTH).

    The ISTH is the leading worldwide organization dedicated to the advancement of the understanding, prevention, diagnosis and treatment of thrombotic and bleeding disorders.

  • curATalk Gwendalyn Randolph - 08.05.2024

    Dissemination of inflammatory cells and molecules from the intestine to downstream and distal organs

    08.05.2024, 17 - 17:45 Uhr

    Prof. Dr. Gwendalyn Randolph

    Emil R. Unanue Professor of Immunobiology, Department of Pathology

    Washington University in St. Louis, USA

  • curATalk Laura Bindila - 18.04.2024

    Modern lipidomics approaches for clinical and preclinical research and profiling

    18.04.2024, 17 - 17:45 Uhr

    Dr. Laura Bindila

    Clinical Lipidomics Unit, Institute of Physiological Chemistry

    University Medical Center Mainz

  • Start of the curATime Fellowship Program at TRON

    curAFellows are aimed at students who would like to gain first practical experience in interdisciplinary research projects in the field of translational research. A unique opportunity to make a valuable contribution to the fight against atherothrombosis at an early stage.

curATalk Seminar series

The curATalk lecture series was created in 2021 in order to connect the scientists that are involved in curATime as well as thematically closely related scientist and their research. This virtual meeting takes place at regular intervals and presents their latest research findings and topics that provide additional scientific value for the individual curATime projects. The curATalks are announced publicly and enjoy lively participation from a broad audience.

curATalks
  • curATalk Alice Assinger - 13.06.2024

    Platelets in Infection: A Battle of Wits

    13.06.2024, 17:15 - 18:15

    Prof. Dr. Alice Assinger

    Institute of Vascular Biology and Thrombosis Research,

    Medical University of Vienna, Austria

    The seminar will be held on-site at University Medical Center Mainz, Building 708

  • curATalk Gwendalyn Randolph - 08.05.2024

    Dissemination of inflammatory cells and molecules from the intestine to downstream and distal organs

    08.05.2024, 17 - 17:45 Uhr

    Prof. Dr. Gwendalyn Randolph

    Emil R. Unanue Professor of Immunobiology, Department of Pathology

    Washington University in St. Louis, USA

  • curATalk Laura Bindila - 18.04.2024

    Modern lipidomics approaches for clinical and preclinical research and profiling

    18.04.2024, 17 - 17:45 Uhr

    Dr. Laura Bindila

    Clinical Lipidomics Unit, Institute of Physiological Chemistry

    University Medical Center Mainz

  • curATalk Stefan Engelhardt - 15.01.2024

    Macrophage-targeted RNA therapeutics

    15.01.2024, 17 - 17:45 Uhr

    Prof. Dr. Dr. Stefan Engelhardt

    Institute of Pharmacology and Toxicology

    Technical University of Munich

    Speaker of the CNATM Cluster

  • curATalk Christoph Reinhardt - 08.11.2023

    Microbiota and Arterial Thrombosis

    08.11.2023, 17 - 17:45 Uhr

    Jun.-Prof. Dr. Christoph Reinhardt

    Center for Thrombosis and Haemostasis

    University Medical Center Mainz, Germany

  • curATalk Muhammad Nabeel Asim - 08.08.2023

    Protein Protein interaction prediction in our AI based Genomics and Proteomics Sequence Analysis Framework

    08.08.2023, 17 - 17:45 Uhr

    Dr. Muhammad Nabeel Asim

    DFKI GmbH

    Kaiserslautern, Germany

  • curATalk Klaus Ley - 12.06.2023

    Breaking Tolerance: The Autoimmune Aspect of Atherosclerosis

    12.06.2023, 17 - 17:45 Uhr

    Prof. Dr. Klaus Ley

    Immunology Center of Georgia

    Augusta University, USA

  • curATalk Johnny Kim - 25.05.2023

    Synthetic regeneration at the heart of reversible reprogramming

    25.05.2023, 17:00 - 17:45 Uhr

    Dr. Johnny Kim

    TRON gGmbH, Mainz

  • curATalk Christoph Binder - 23.11.2022

    „Humoral“ Immunity and Immune Homeostasis in Atherosclerosis

    23.11.2022, 17:00 - 17:45 Uhr

    Prof. Dr. Christoph Binder
    Department of Laboratory Medicine Medical University of Vienna & Center for Molecular Medicine of the Austrian Academy of Sciences

  • curATalk Markus Jostock - 21.03.2023

    Blockchain as Digital Access Gate to Medical Data

    21.03.2023, 17:00 - 17:45 Uhr

    Dr. Markus Jostock

    Arxum GmbH, Kaiserslautern

  • curATalk David Leistner - 17.01.2023

    Acute coronary syndrome – novel pathophysiologic insights call for precision prevention

    17.01.2023, 17:00 - 17:45 Uhr

    Prof. Dr. David M. Leistner

    Med. Clinic 3 – Cardiology, Angiology, University Hospital Frankfurt

  • curATalk Lutz Nuhn - 06.09.2022

    Macromolecular strategies for enhancing immunotherapy responses to treat cardiovascular diseases

    06.09.2022, 17:00 - 17:45 Uhr

    Prof. Lutz Nuhn

    Julius Maximilian University Würzburg

  • curATalk Florian Leuschner - 21.07.2022

    Inflammation of the heart: Mechanism and therapeutic options

    21.07.2022, 16:00 – 16:45 Uhr

    Prof. Dr. med. Florian Leuschner

    Heidelberg University Hospital

  • curATalk Hugo ten Cate - 21.06.2022

    Atherothrombosis: the impact of clotting proteases
    21.06.2022 17:30 - 18:15 Uhr
    Prof. Hugo ten Cate
    CARIM, Maastricht University Medical Center+

  • curATalk Stefanie Dimmeler - 12.04.2022

    RNA therapeutics in cardiovascular disease

    12.04.2022, 17:00 - 18:00 Uhr

    Prof. Dr. Stefanie Dimmeler

    Goethe- University, Frankfurt

    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine

  • curATalk Johan Trygg - 23.03.2022

    Chemometrics strategies and tools in Precision Medicine

    23.03.2022 17:30 - 18:15 Uhr

    Prof. Johan Trygg

    Departmentof Chemistry, Umeå University, Umeå, Sweden

    Corporate Research, Sartorius, Umeå, Sweden

  • curATalk Jürgen Scheele - 22.03.2022

    Artificial CRISPR, an AI based approach to predict signature drug response from multi-omics datasets

    22.03.2022, 17:30 - 18:15 Uhr

    Prof. Dr. Jürgen Scheele

    Chief Medical Officer Innoplexus AG

  • curATalk Abdelhak Zoubir - 15.02.2022

    Advancing Robust Signal Processing and Statistical Learning for Biomedical Applications

    15.02.2022, 17:30 - 18:15 Uhr

    Prof. Dr.-Ing. Abdelhak Zoubir

    Signal Processing Group, Technical University of Darmstadt

  • curATalk Sara Vieira-Silva - 02.02.2022

    Human gut microbiota variation in health and disease

    02.02.2022, 17:00 – 17:45 Uhr

    Sara Vieira-Silva, PhD

    Laboratory of Molecular Bacteriology (Rega Institute), KU Leuven, Belgium

  • curATalk Jama Nateqi - 24.01.2022

    Symptoma – Every patient deserves the right diagnosisand treatment

    24.01.2022, 17:00 - 17:45 Uhr

    Dr. med-univ. Jama Nateqi

    Symptoma GmbH

  • curATalk Stefan Tenzer - 15.12.2021

    Mass spectrometry-based proteomics in translational research and systems medicine
    15.12.2021, 17:30 – 18:15 Uhr
    Univ.-Prof. Dr. rer. nat. Stefan Tenzer
    Institut für Immunologie, Universitätsmedizin Mainz

curAHack - 1st curATime Hackathon

Innovate the future of Life Science and Medicine

curAHack has brought together young scientists, bioinformaticians and healthcare-enthusiasts to tackle research challenges from the curATime cluster. With guidance from mentors and experts, participants have developed innovative solutions presented their ideas to a jury at the end of the event. More information about the challenges and the event itself can be found here.

The mentors of the three challenges draw an enthusiastic conclusion:

"Team 1 , "curAGUI" was required to create a GUI that was able to implement all of the placeholder scripts provided in order to further on be able to replace them with trained deep learning models. The team was able to develop a basic framework that meant to envelop all of the required points and integrated videos in a manner that would mimic the results of the pipeline."

Aida Romano Martínez, University Medical Center Mainz

"During the hackathon, two teams worked on an RNA-seq analysis pipeline that should not require any gene annotation information for initial analysis. Both teams were able to conduct exploratory analysis to quantify the effect of different ensemble gene annotation models. As a solution, both teams came up with k-mer count tables as an intermediate result file that can later be mapped to any gene annotation.

While one team, the "Bioinformagicians", established an analysis pipeline using existing tools that they cleverly selected and adapted for the intended use, the other team, the "Expressionists", developed a novel analysis from scratch. The Bioinformagicians ultimately won the hackathon with a combined analysis that could be the basis for the development of novel expression pipeline for RNA-seq data. We will summarize all results and findings in a preprint and make all data, code, and analysis available as public repository and on a preprint server."

Dr. David Weber, TRON gGmbH

"The Hackathon challenge “Target Sequence for RNA delivery” was tackled by the team “CurApollo13” that aimed to identify peptide sequences that could enable targeted delivery of nanoparticles to endothelial cells within atherosclerotic lesions. Without any prior knowledge or computational resources, the team came up with two creative and yet complementary concepts. One approach involved analysis of 3D protein structures of paratope/epitope pairs.

In a second approach, the CurApollo13-team provided a concept wherein 3D structures of random short peptide sequences could be computationally predicted using AlphaFold, a powerful computational method that can simulate 3D protein structures. Conceptually, these putative structures could be superimposed on to antigens to test their putative binding. In principle, the first approach could be used to validate the second, fully computational approach.  Team CurApollo13 finished as the runners-up of the curAHack."

Dr. Johnny Kim, TRON gGmbH

curAHack 2024 at the Gutenberg Digital Hub at the Zollhafen Mainz.