curATalk Heinz Handels - 16.01.2025
AI in Medical Image Computing
16.01.2025, 5:00 - 5:45 PM
Department of Artificial Intelligence in Medical Image and Signal Processing, DFKI Lübeck
Institute of Medical Informatics, University of Lübeck
News und Events
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Register now for our next 2.5 days (Bio-) Hackathon “curAHack” on March 31 - April 02.2025 in Mainz
Interdisciplinary hacking, problem solving and networking: The event is open to all disciplines and career levels (students are welcome!). During the hacking sessions, you will be supported by a mentor. The best teams will win prizes.
We are looking forward to seeing you in spring!
Check out our 5 challenges here: curahack-challenges-2025.pdf
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curATalk Miguel Andrade - 02.12.2024
„Computational approaches for the prediction of gene and protein function“
02.12.2024, 5:00 - 5:45 pm
Computational Biology and Data Mining Group, JGU Mainz
Das Seminar will be held on-site at TRON gGmbH, Goettelmannstrasse 17, Mainz, seminar room ground floor right .
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curATalk Martin Zörnig - 26.11.2024
Introducing ForTra - Promoting the translation of medical research results into clinical application
26.11.2024, 17 - 17:45 Uhr
ForTra gGmbH für Forschungstransfer der Else-Kröner-Fresenius-Stiftung, Bad Homburg v.d. Höhe
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Vernetzungsveranstaltung der BioVation RLP - wir sind mit dabei!
Markus Junker, unser Mitglied im curATime-Management Team, vom DFKI leitet den Workshop „KI in Life Sciences: Potenziale und Herausforderungen“, in dem unser Clustersprecher Prof. Johnny Kim curATime vorstellen wird. Außerdem beteiligt sich Prof. Andreas Dengel, Geschäftsführender Direktor des DFKI, an der Podiumsdiskussion "Vernetzung regionaler Technologiezentren in RLP" und unser curATime Projektleiter und Lotse für KI und Life Science, Prof. Stefan Kramer von der Johannes Gutenberg-Universität spricht über “KI und Life Science in Rheinland-Pfalz”.
curATalk Seminar Series
The curATalk lecture series was created in 2021 in order to connect the scientists that are involved in curATime as well as thematically closely related scientist and their research. This virtual meeting takes place at regular intervals and presents their latest research findings and topics that provide additional scientific value for the individual curATime projects. The curATalks are announced publicly and enjoy lively participation from a broad audience.
curATalks
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curATalk Heinz Handels - 16.01.2025
AI in Medical Image Computing
16.01.2025, 5:00 - 5:45 PM
Department of Artificial Intelligence in Medical Image and Signal Processing, DFKI Lübeck
Institute of Medical Informatics, University of Lübeck
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curATalk Miguel Andrade - 02.12.2024
„Computational approaches for the prediction of gene and protein function“
02.12.2024, 5:00 - 5:45 pm
Computational Biology and Data Mining Group, JGU Mainz
Das Seminar will be held on-site at TRON gGmbH, Goettelmannstrasse 17, Mainz, seminar room ground floor right .
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curATalk Martin Zörnig - 26.11.2024
Introducing ForTra - Promoting the translation of medical research results into clinical application
26.11.2024, 17 - 17:45 Uhr
ForTra gGmbH für Forschungstransfer der Else-Kröner-Fresenius-Stiftung, Bad Homburg v.d. Höhe
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curATalk Bernd Engelmann - 06.11.2024
„Immune cell specificity of immunothrombosis control“
06.11.2024, 5:15 - 6 pm
Institute for Laboratory Medicine,
University Hospital of Munich (LMU Klinikum)The seminar will take place on-site at the University Medical Center Campus Mainz Building 708, Seminar room 2.
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curATalk Lena Seegers - 31.10.2024
Sex differences in coronary artery disease
31.10.2024, 17:00 - 18:00 Uhr
Universitätsklinikum Frankfurt am Main, Medizinische Klinik 3: Kardiologie, Angiologie
The seminar will be held on-site at the University Medical Center Mainz Campus, building 102, seminar room 1.
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curATalk Laura Zelarayán-Behrend - 02.10.2024
Restoration of endogenous transcription factor activity by CRISPRa to prevent cardiac failure
02.10.2024, 17 - 18:00 Uhr
Institute of Phamacology and Toxicology,
University Medical Center Göttingen
The seminar will be held on-site at the University Medical Center Mainz, Building 708
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curATalk Florian A. Weinberger - 02.10.2024
Pluripotent stem cell derived cardiomyocytes for cardiac repair - pharmacological considerations
02.10.2024, 17 - 18:00 Uhr
Spanish National Center for Cardiovascular Research, Madrid
& Medical Center Hamburg-Eppendorf
The seminar will be held on-site at University Medical Center Mainz, Building 708
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curATalk Alice Assinger - 13.06.2024
Platelets in Infection: A Battle of Wits
13.06.2024, 17:15 - 18:15
Institute of Vascular Biology and Thrombosis Research,
Medical University of Vienna, Austria
The seminar will be held on-site at University Medical Center Mainz, Building 708 -
curATalk Gwendalyn Randolph - 08.05.2024
Dissemination of inflammatory cells and molecules from the intestine to downstream and distal organs
08.05.2024, 17 - 17:45 Uhr
Emil R. Unanue Professor of Immunobiology, Department of Pathology
Washington University in St. Louis, USA
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curATalk Laura Bindila - 18.04.2024
Modern lipidomics approaches for clinical and preclinical research and profiling
18.04.2024, 17 - 17:45 Uhr
Clinical Lipidomics Unit, Institute of Physiological Chemistry
University Medical Center Mainz
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curATalk Stefan Engelhardt - 15.01.2024
Macrophage-targeted RNA therapeutics
15.01.2024, 17 - 17:45 Uhr
Prof. Dr. Dr. Stefan Engelhardt
Institute of Pharmacology and Toxicology
Technical University of Munich
Speaker of the CNATM Cluster
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curATalk Christoph Reinhardt - 08.11.2023
Microbiota and Arterial Thrombosis
08.11.2023, 17 - 17:45 Uhr
Jun.-Prof. Dr. Christoph Reinhardt
Center for Thrombosis and Haemostasis
University Medical Center Mainz, Germany
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curATalk Muhammad Nabeel Asim - 08.08.2023
Protein Protein interaction prediction in our AI based Genomics and Proteomics Sequence Analysis Framework
08.08.2023, 17 - 17:45 Uhr
Dr. Muhammad Nabeel Asim
DFKI GmbH
Kaiserslautern, Germany
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curATalk Klaus Ley - 12.06.2023
Breaking Tolerance: The Autoimmune Aspect of Atherosclerosis
12.06.2023, 17 - 17:45 Uhr
Prof. Dr. Klaus Ley
Immunology Center of Georgia
Augusta University, USA
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curATalk Johnny Kim - 25.05.2023
Synthetic regeneration at the heart of reversible reprogramming
25.05.2023, 17:00 - 17:45 Uhr
Dr. Johnny Kim
TRON gGmbH, Mainz
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curATalk Christoph Binder - 23.11.2022
„Humoral“ Immunity and Immune Homeostasis in Atherosclerosis
23.11.2022, 17:00 - 17:45 Uhr
Prof. Dr. Christoph Binder
Department of Laboratory Medicine Medical University of Vienna & Center for Molecular Medicine of the Austrian Academy of Sciences -
curATalk Markus Jostock - 21.03.2023
Blockchain as Digital Access Gate to Medical Data
21.03.2023, 17:00 - 17:45 Uhr
Dr. Markus Jostock
Arxum GmbH, Kaiserslautern
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curATalk David Leistner - 17.01.2023
Acute coronary syndrome – novel pathophysiologic insights call for precision prevention
17.01.2023, 17:00 - 17:45 Uhr
Prof. Dr. David M. Leistner
Med. Clinic 3 – Cardiology, Angiology, University Hospital Frankfurt
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curATalk Lutz Nuhn - 06.09.2022
Macromolecular strategies for enhancing immunotherapy responses to treat cardiovascular diseases
06.09.2022, 17:00 - 17:45 Uhr
Julius Maximilian University Würzburg
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curATalk Florian Leuschner - 21.07.2022
Inflammation of the heart: Mechanism and therapeutic options
21.07.2022, 16:00 – 16:45 Uhr
Prof. Dr. med. Florian Leuschner
Heidelberg University Hospital
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curATalk Hugo ten Cate - 21.06.2022
Atherothrombosis: the impact of clotting proteases
21.06.2022 17:30 - 18:15 Uhr
Prof. Hugo ten Cate
CARIM, Maastricht University Medical Center+ -
curATalk Stefanie Dimmeler - 12.04.2022
RNA therapeutics in cardiovascular disease
12.04.2022, 17:00 - 18:00 Uhr
Prof. Dr. Stefanie Dimmeler
Goethe- University, Frankfurt
Institute of Cardiovascular Regeneration, Centre for Molecular Medicine
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curATalk Johan Trygg - 23.03.2022
Chemometrics strategies and tools in Precision Medicine
23.03.2022 17:30 - 18:15 Uhr
Prof. Johan Trygg
Departmentof Chemistry, Umeå University, Umeå, Sweden
Corporate Research, Sartorius, Umeå, Sweden
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curATalk Jürgen Scheele - 22.03.2022
Artificial CRISPR, an AI based approach to predict signature drug response from multi-omics datasets
22.03.2022, 17:30 - 18:15 Uhr
Prof. Dr. Jürgen Scheele
Chief Medical Officer Innoplexus AG
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curATalk Abdelhak Zoubir - 15.02.2022
Advancing Robust Signal Processing and Statistical Learning for Biomedical Applications
15.02.2022, 17:30 - 18:15 Uhr
Prof. Dr.-Ing. Abdelhak Zoubir
Signal Processing Group, Technical University of Darmstadt
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curATalk Sara Vieira-Silva - 02.02.2022
Human gut microbiota variation in health and disease
02.02.2022, 17:00 – 17:45 Uhr
Laboratory of Molecular Bacteriology (Rega Institute), KU Leuven, Belgium
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curATalk Jama Nateqi - 24.01.2022
Symptoma – Every patient deserves the right diagnosisand treatment
24.01.2022, 17:00 - 17:45 Uhr
Dr. med-univ. Jama Nateqi
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curATalk Stefan Tenzer - 15.12.2021
Mass spectrometry-based proteomics in translational research and systems medicine
15.12.2021, 17:30 – 18:15 Uhr
Univ.-Prof. Dr. rer. nat. Stefan Tenzer
Institut für Immunologie, Universitätsmedizin Mainz
curAMeet 2024 - Our First Cluster Conference
“Translating Research into Therapies” was the motto of our first cluster conference on February 6th, which brought together all cluster stakeholders to discuss current research issues and results in a relaxed atmosphere.
External experts from a variety of fields such as translational research, AI, thrombosis research and sustainability in science not only gave our members fresh perspectives with their presentations, but also expanded our network. In addition, renowned speakers from politics and BMBF representatives once again highlighted the importance of our cluster and reinforced our joint mission.
Afterwards, our lighthouse projects were presented within short presentations and all of our other curATime projects were discussed intensively during the poster session - a very good opportunity to strengthen personal contacts within the cluster.
Our conference day ended by handing out the “curAEquality” award: we awarded special research achievements in the field of gender and diversity for the first time. The winner, Romina Wolz, who is currently working on her doctoral thesis at the Center for Thrombosis and Haemostasis at the University Medical Center Mainz, received the award for her curATime sub-project “Role of macrophage coagulation signaling in atherosclerosis”.
Postersession at the curAMeet 2024
curAHack - 1st curATime Hackathon
Innovate the future of Life Science and Medicine
curAHack has brought together young scientists, bioinformaticians and healthcare-enthusiasts to tackle research challenges from the curATime cluster. With guidance from mentors and experts, participants have developed innovative solutions presented their ideas to a jury at the end of the event. More information about the challenges and the event itself can be found here.
The mentors of the three challenges draw an enthusiastic conclusion:
"Team 1 , "curAGUI" was required to create a GUI that was able to implement all of the placeholder scripts provided in order to further on be able to replace them with trained deep learning models. The team was able to develop a basic framework that meant to envelop all of the required points and integrated videos in a manner that would mimic the results of the pipeline."
Aida Romano Martínez, University Medical Center Mainz
"During the hackathon, two teams worked on an RNA-seq analysis pipeline that should not require any gene annotation information for initial analysis. Both teams were able to conduct exploratory analysis to quantify the effect of different ensemble gene annotation models. As a solution, both teams came up with k-mer count tables as an intermediate result file that can later be mapped to any gene annotation.
While one team, the "Bioinformagicians", established an analysis pipeline using existing tools that they cleverly selected and adapted for the intended use, the other team, the "Expressionists", developed a novel analysis from scratch. The Bioinformagicians ultimately won the hackathon with a combined analysis that could be the basis for the development of novel expression pipeline for RNA-seq data. We will summarize all results and findings in a preprint and make all data, code, and analysis available as public repository and on a preprint server."
Dr. David Weber, TRON gGmbH
"The Hackathon challenge “Target Sequence for RNA delivery” was tackled by the team “CurApollo13” that aimed to identify peptide sequences that could enable targeted delivery of nanoparticles to endothelial cells within atherosclerotic lesions. Without any prior knowledge or computational resources, the team came up with two creative and yet complementary concepts. One approach involved analysis of 3D protein structures of paratope/epitope pairs.
In a second approach, the CurApollo13-team provided a concept wherein 3D structures of random short peptide sequences could be computationally predicted using AlphaFold, a powerful computational method that can simulate 3D protein structures. Conceptually, these putative structures could be superimposed on to antigens to test their putative binding. In principle, the first approach could be used to validate the second, fully computational approach. Team CurApollo13 finished as the runners-up of the curAHack."
Dr. Johnny Kim, TRON gGmbH
curAHack 2024 at the Gutenberg Digital Hub at the Zollhafen Mainz.
